I've been reading more and more about people's fantastic weight loss with these peptides. Tirzepatide is more effective and had fewer reported side effects, but is only FDA approved (as of now) for T2 diabetes. Only Wegovy is FDA approved for weight loss, but I read Mounjaro/Tizepatide is being fast tracked for this.

On Tirzepatide, the average (!) weight loss was 15% of body weight at 72 weeks. There have been anecdotal reports of insane weight loss and people having to remind themselves to eat. Tirzepatide can be prescribed by docs off label, but the cost is double and probably not covered by insurance.

Anyone using any of these? I'm thinking to trying out Semaglutide. Will post results if I do. I'm not morbidly obese or anything like that, but have had stubborn weight I can't lose with my regular dieting/exercise. I was single when I was at my goal weight of 175, but I'm not single anymore and there is all kinds of tempting food in the house now. I also have sleep apnea and HBP poorly controlled by drugs, so any weight loss would be awesome.

https://www.nejm.org/doi/full/10.1056/NEJMoa2107519

My husband is on Mounjaro and has lost about 40 pounds in two months (from 280 to 240). He is 6'2". It is super expensive at $1000/per month though. For the first few weeks until his body adjusted, he would get nauseated when he ate. The issue was that it did not lessen his appetite, just made him feel sick when he ate. He has stalled the last few weeks and I have told him to start lifting some weights and do some walking to re-start the weight loss.

Been on Mounjaro since Nov. Went from 255 to 200ish. Definitely can't eat the volume of food as I used to. But do need to eat, don't try to starve/skip meals. That is when I can over eat.

On the 10mg dose, tried to get a refill for over a week. Non available, and didn't know when they'd get more. Decided to get a lower dose, definitely been harder.

GeorgiAg said:

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I've been reading more and more about people's fantastic weight loss with these peptides. Tirzepatide is more effective and had fewer reported side effects, but is only FDA approved (as of now) for T2 diabetes. Only Wegovy is FDA approved for weight loss, but I read Mounjaro/Tizepatide is being fast tracked for this.

On Tirzepatide, the average (!) weight loss was 15% of body weight at 72 weeks. There have been anecdotal reports of insane weight loss and people having to remind themselves to eat. Tirzepatide can be prescribed by docs off label, but the cost is double and probably not covered by insurance.

Anyone using any of these? I'm thinking to trying out Semaglutide. Will post results if I do. I'm not morbidly obese or anything like that, but have had stubborn weight I can't lose with my regular dieting/exercise. I was single when I was at my goal weight of 175, but I'm not single anymore and there is all kinds of tempting food in the house now. I also have sleep apnea and HBP poorly controlled by drugs, so any weight loss would be awesome.

https://www.nejm.org/doi/full/10.1056/NEJMoa2107519

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KidDoc has several posts about these drugs:

https://texags.com/forums/48/topics/3353355/replies/64024211

https://texags.com/forums/48/topics/3362733/replies/64327648

Edit to add - those are a starting point. I'd just search his ID and read his posts on it.

Seems like they are just starting to discover some of the drawbacks to these drugs. Seen some people who've had real issues with them.

Probably a good choice for the morbidly obese. But for those of us trying to lose a few pounds to better our 10K time, probably a poor choice.

We manage these meds

The hard part is insurance coverage

I found a compounding pharmacy that I trust so now can offer to patients for a fraction of the price

A better strength training and cardio regimen would probably do more to help your HBP and curb your sleep apnea than shortcutting a few pounds you'll likely gain back immediately.

My FIL is on Ozempic. He has lost weight but has also lost quite a bit of muscle mass. Be careful.
Also, I don't believe these are really long term prescriptions simply for weight loss and once you stop the meds you gain the weight back (and then some) quickly.

I believe the drugs are the most useful when paired with some sort of program or oversight by a professional who helps the patient learn better eating habits and prove they can eat more sustainably….then slowly get weaned off the drug to make a bounceback less likely

Don't forget about "Ozempic Face" too. I know a woman who used it. She's probably mid 30s. She looks like she's in her 60s in the face because of how haggard she looks.

I've also heard this can affect the uh....bottom...as well.

AJ02 said:

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Don't forget about "Ozempic Face" too. I know a woman who used it. She's probably mid 30s. She looks like she's in her 60s in the face because of how haggard she looks.

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That's mostly the effect of losing weight / fat in the face. When I've lost weight, I've always looked older and when I gain it back I look younger (and fatter). Our skin isn't as elastic when we age, so losing layers underneath has an effect on the exterior.

I don't want to do it for vanity. I have high blood pressure controlled by meds and also my A1C is getting shaky. That's the primary reason.

Although losing weight is good for self esteem and I can fit in some of my expensive suits again.

AJ02 said:

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Don't forget about "Ozempic Face" too. I know a woman who used it. She's probably mid 30s. She looks like she's in her 60s in the face because of how haggard she looks.

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I think non-Ozempic fat face is worse, especially for the morbidly obese.

https://www.reddit.com/r/Ozempic/top/?t=all

GeorgiAg said:

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I don't want to do it for vanity. I have high blood pressure controlled by meds and also my A1C is getting shaky. That's the primary reason.

Although losing weight is good for self esteem and I can fit in some of my expensive suits again.

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I'd recommend looking into intermittent fasting and a low carb diet. Eating multiple small meals and following the food pyramid is a prescription for type 2 diabetes for many.

Nice to see some people actually reading my posts!

These drugs are amazing. As already mentioned you better be on vitamins and exercising even when on them as they will dramatically curb your appetite and eating volume. For me they did not change the pleasure of eating just the volume. I was on Wegovy for about a year and dropped 50 lbs. Been off for 9 months and crept up 15 but most of that was due to a few recent vacations and I'm beating it back down at the moment.

They offer real hope for treatment but if you don't change your caloric balance/activity you are going to rebound as already mentioned.

All of the side effects are 100% predictable. If you don't cut your portions in half you are going to be bloated. Getting pancreatitis is not a shock if you aren't eating and get biliary stasis. Having ozempic face from abrupt fat loss is completely expected.

I'm hoping that cost will come down as competition heats up in the GLP-1 market. There are oral formulations that are also looking very promising.

These drugs have been out for years, I wouldn't wait especially if your insurance covers it, you have BMI > 30 especially with comorbidities. As mentioned I would not start them to drop that last 15 lbs.

Thanks. I'm on semaglutide. 1 week. 3-4 pounds down.

Felt sick the first day. No problems since. When I do extreme keto, I can lose weight, but I have to be extreme to do so. I'm gonna try this for a little while and see what happens. If I could lose 40 pounds, I'd be at my perfect weight.

Started long walks and increased my weight lifting.

What dosage did you start at?

As a tip, I do enjoy playing games and testing myself. For example, I wake up, I still feel full from last night, I'm not going to eat today until I feel hungry. They usually runs into the afternoon that I take my first bite of the day (still drink caffeine in the morning.)

Or I'm going to order a kids meal at lunch and see if I feel hungry before dinner. If I do, I'll have a snack. If I don't, I won't.

Make sure you are watching the quality of your food too given the lower volume. I focus on veggies, fruit, protein to try to make sure I'm getting enough nutrition.

Again, if you overeat, you'll probably only do it once. It's pretty miserable.

The starting dose. .25mg. We'll. See how it goes.

I've mostly been eating only once a day.

dlp3719 said:

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What dosage did you start at?

As a tip, I do enjoy playing games and testing myself. For example, I wake up, I still feel full from last night, I'm not going to eat today until I feel hungry. They usually runs into the afternoon that I take my first bite of the day (still drink caffeine in the morning.)

Or I'm going to order a kids meal at lunch and see if I feel hungry before dinner. If I do, I'll have a snack. If I don't, I won't.

Make sure you are watching the quality of your food too given the lower volume. I focus on veggies, fruit, protein to try to make sure I'm getting enough nutrition.

Again, if you overeat, you'll probably only do it once. It's pretty miserable.

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Yeah I ate a whole whataburger- no fries just plain ole burger when I first started Wegovy and man I was bloated!

I was on Monjauro but due to the shortages my Endocrinologist put me on Ozempic.

I have lost quite a bit of weight, but also changed my lifestyle, got my sleep apnea treated, and now workout 5 days a week, incorporating cardio and weights.

Happy to answer any questions!

I was in Mounjaro for one year, lost 46 lbs.
Coupon expired and I'm not going to pay 1200 a month for it, so I'm probably going to use compound semaglutide for awhile

What is everyone paying for this? I have seen a few at $1000+ a month, but I assume that these are without insurance. I need to go to my doctor to get checked out, but I have no doubt I should qualify in the obese category, just need to check with my insurance to confirm what their coverage is. Thanks.

Ags-R-Better said:

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What is everyone paying for this? I have seen a few at $1000+ a month, but I assume that these are without insurance. I need to go to my doctor to get checked out, but I have no doubt I should qualify in the obese category, just need to check with my insurance to confirm what their coverage is. Thanks.

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My insurance was covering it with bmi > 30 for $35 a month or so. Once I dropped below 30 bmi they no longer covered it and now they aren't covering Wegovy at all but they do cover Mounjaro. So it really depends on your specific insurance policy. Many policies specifically state they don't cover any weight loss treatment period. Medicare/Medicaid fall in this category they only will help patients once they are sick due to obesity not for prevention or correction of obesity/metabolic disorder.

I just started it myself. Sample of ozempic .5mg q wk. plus keto. Dropped 5#s in 2 weeks. Need to lose 40. Appetite less for sure and full quickly. Problem is my insurance wont cover it cause I am not fat enough. Anyone have experience with the compounding formulations?